凝固因子C4（Clotting Factor C4）
| 型 号： | 美国Seracare |
| 报 价： |  |
美国Seracare凝固因子C4（Clotting Factor C4） 阳性质控品对照品 需要了解更多Seracare产品可以咨询我们，本产品由广州健仑生物科技有限公司提供
- 产品描述
美国Seracare凝固因子C4（Clotting Factor C4）
广州健仑生物科技有限公司
广州健仑长期供应各种生物原料，主要代理品牌：美国Seracare、西班牙Certest、美国Fuller等等。
主要产品包括各种标准品、阳性对照品、单克隆抗原抗体。
其中常见的有：弓形虫病、西尼罗河病毒、类风湿因子、疟疾、麻疹、莱姆病、百日咳杆菌、大肠杆菌、鼠伤寒沙门氏菌、李斯特菌等阳性对照品。
美国Seracare凝固因子C4（Clotting Factor C4）
我司还提供其它进口或国产试剂盒：登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、化妆品检测、食品安全检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。
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【Seracare产品介绍】
编号 | 英文名称 | 中文名称 |
JL-FA-01 | Amebiasis (AME) | 阿米巴病 |
JL-FA-02 | Allergens, Rast scores | 过敏原，放射性过敏原吸收实验。指对特定的人群引起免疫反应或者过敏反应的食品中的蛋白质 |
JL-FA-03 | Allergens, Rast scores negative | 过敏原，放射性过敏原吸收实验阴性 |
JL-FA-04 | Anti-cyclic citrullinated peptide Antibody (CCP) Arthritis | 抗环瓜氨酸肽抗体 |
JL-FA-05 | ASCA Saccharomyces Cerevi | 人抗酿酒酵母抗体（ASCA） |
JL-FA-06 | Aspergillis | 麴菌病 |
JL-FA-07 | Beta 2 Glycoprotein | β2糖蛋白 |
JL-FA-08 | Beta 2 Glycoprotein IgM | β2糖蛋白 IGM |
JL-FA-09 | Bordela Pertussis | 百日咳杆菌 |
JL-FA-10 | Bordela Pertussis IgM | 百日咳杆菌 IGM |
JL-FA-11 | C-ANCA | C-抗中性粒细胞胞浆抗体（ANCA) |
JL-FA-12 | Cardiolipin | 心肌磷脂 |
JL-FA-13 | Cardiolipin IgA | 心肌磷脂 IGA |
JL-FA-14 | Cardiolipin IgG | 心肌磷脂 IGG |
JL-FA-15 | Cardiolipin IgM | 心肌磷脂 IGM |
JL-FA-16 | Cerebral Spinal Fluid | 脑脊髓液 |
JL-FA-17 | Chagas | 恰加斯病/南美锥虫 |
JL-FA-18 | Chlamydia | 衣原体 |
JL-FA-19 | Chlamydia IgA | 衣原体IGA |
JL-FA-20 | Chlamydia IgG | 衣原体IGG |
JL-FA-21 | Chlamydia IgM | 衣原体IGM |
JL-FA-22 | Chlamydia Neg | 衣原体阴性 |
JL-FA-23 | Clotting Factor C3 | 凝固因子C3 |
JL-FA-24 | Clotting Factor C4 | 凝固因子C4 |
JL-FA-25 | Coccidiodes | 球孢菌 |
JL-FA-26 | Cytomegalovirus (CMV) Neg | 巨细胞病毒抗体阴性 |
JL-FA-27 | CMV IgG | 巨细胞病毒 IGG阳性 |
JL-FA-28 | CMV IgM VCA | 巨细胞病毒 IGM 阳性 |
JL-FA-29 | C-Reactive Protein (CRP) | C-反应蛋白质 |
JL-FA-30 | Dengue Fever | 登革热 |
JL-FA-31 | Dengue Fever IgM | 登革热 IGM |
JL-FA-32 | DS (Double Stranded) DNA | 双链脱氧核糖核酸 |
JL-FA-33 | EBNA (Epstein-Barr nuclear antigen) IgG | EB病毒核抗原 IGG |
JL-FA-34 | EBNA (Epstein-Barr nuclear antigen) IgM | EB病毒核抗原 IGM |
JL-FA-35 | Epstein Barr Virus (EBV) Negative Plasma | EB病毒阴性血浆 |
JL-FA-36 | Epstein Barr Virus (EBV) EA IgM | EB病毒早期抗原 IGM |
JL-FA-37 | Epstein Barr Virus (EBV) VCA IgM | EB病毒壳蛋白 IGM |
JL-FA-38 | Epstein Barr Virus (EBV) EA IgG | EB病毒早期抗原 IGG |
JL-FA-39 | EMA (Endomysial Antibodies) | 肌内膜 |
JL-FA-40 | Gliadin | 麸蛋白,麦醇溶蛋白,麦胶蛋白 |
JL-FA-41 | Gliadin IgG | 麦醇溶蛋白 IGG |
JL-FA-42 | Gliadin IgA | 麦醇溶蛋白 IGA |
JL-FA-43 | Glomerular Basement Membrane (GBMA) | 肾小球基底膜病 |
JL-FA-44 | Helicobacter pylori IgA | 幽门螺旋杆菌IGA |
JL-FA-45 | Helicobacter pylori IgG | 幽门螺旋杆菌IGG |
JL-FA-46 | Helicobacter pylori IgM | 幽门螺旋杆菌IGM |
JL-FA-47 | Helicobacter pylori Negative | 幽门螺旋杆菌阴性 |
JL-FA-48 | Helicobacter pylori Positive Plasma | 幽门螺旋杆菌阴性血浆 |
JL-FA-49 | Hepatitis A Virus (HAV) Pos. Plasma | 甲型肝炎病毒阳性血浆 |
JL-FA-50 | Hepatitis A Virus (HAV) IgM | 甲型肝炎病毒IGM |
JL-FA-51 | Hepatitis B Core (HBc) IgG | 乙型肝炎病毒核心 IGG |
JL-FA-52 | Hepatitis B Core (HBc) IgM | 乙型肝炎病毒核心 IGM |
JL-FA-53 | Anti Hbe (Antibody to HBV antigen) | 乙肝抗体 |
JL-FA-54 | Hepatitis Delta Virus | 丁型肝炎病毒 |
JL-FA-55 | HBeAg (HBV e antigen) | 乙肝 E抗原 |
JL-FA-56 | anti-HBs (HBV surface antibody) | 乙肝表面抗体 |
JL-FA-57 | Hepatitis B (HBsAg) "Chronic" | 乙型肝炎（乙肝表面抗原）“慢性病 |
JL-FA-58 | HBsAg (HBV surface antigen) Serum | 乙肝表面抗原血清 |
JL-FA-59 | HBsAg (AD) | 乙肝表面抗原（AD） |
JL-FA-60 | HBsAg (AY) | 乙肝表面抗原（AY） |
JL-FA-61 | HBV Positive Plasma | 乙肝阳性血浆 |
JL-FA-62 | HBV DNA Plasma | 乙肝DNA血浆 |
JL-FA-63 | HBV DNA Serum | 乙肝DNA血清 |
JL-FA-64 | HBV DNA type A | A型 乙肝DNA |
JL-FA-65 | HBV DNA type B | B型 乙肝DNA |
JL-FA-66 | HBV DNA type C | C型 乙肝DNA |
JL-FA-67 | HBV DNA type D | D型 乙肝DNA |
JL-FA-68 | HBV DNA type E | E型 乙肝DNA |
JL-FA-69 | HBV DNA type F | F型 乙肝DNA |
JL-FA-70 | HBV Antibody HCV Antibody Plasma CO-INFECTED | 乙肝和丙肝联合感染血浆 |
JL-FA-71 | HCV (Hepatitis C Virus) Antibody | 丙型肝炎抗体 |
JL-FA-72 | HCV Core Antigen Positive | 丙肝核心抗原 阳性 |
JL-FA-73 | HCV RNA PLASMA Genotype 1 | 基因1型丙肝RNA 血浆 |
JL-FA-74 | HCV RNA PLASMA Genotype 2 | 基因2型丙肝RNA 血浆 |
JL-FA-75 | HCV RNA PLASMA Genotype 3 | 基因3型丙肝RNA 血浆 |
JL-FA-76 | HCV RNA PLASMA Genotype 4 | 基因4型丙肝RNA 血浆 |
JL-FA-77 | HCV RNA PLASMA Genotype 5 | 基因5型丙肝RNA 血浆 |
JL-FA-78 | HCV RNA PLASMA Genotype 6 | 基因6型丙肝RNA 血浆 |
JL-FA-79 | HCV Riba single band | 丙肝免疫印迹单波段 |
JL-FA-80 | HCV RIBA Pos. (multiple bands) | 丙肝免疫印迹阳性多波段 |
JL-FA-81 | HCV Negative | 丙肝阴性 |
JL-FA-82 | HCV RNA Pos (quantitative) | 丙肝RNA阳性（定量） |
JL-FA-83 | Hepatitis E | 戊型肝炎 |
JL-FA-84 | Herpes Simplex Virus (HSV)1/2 Positive Plasma | 单纯性疱疹病毒1/2阳性血浆 |
JL-FA-85 | Herpes Simplex Virus (HSV) 1 Negative Plasma | 单纯性疱疹病毒1 阴性血浆 |
JL-FA-86 | Herpes Simplex Virus (HSV) 1 IgG | 单纯性疱疹病毒1 IGG |
JL-FA-87 | Herpes Simplex Virus (HSV 1) IgM | 单纯性疱疹病毒1 IGM |
JL-FA-88 | Herpes Simplex Virus (HSV) 2 IgG | 单纯性疱疹病毒2 IGG |
JL-FA-89 | Herpes Simplex Virus (HSV) 2 IgM | 单纯性疱疹病毒2 IGG |
JL-FA-90 | Histone | 组蛋白 |
JL-FA-91 | Human Anti Mouse Ab (HAMA) | 人抗鼠抗体 |
JL-FA-92 | Human immunodeficiency virus (HIV) 1 Neg | HIV I 阴性 |
JL-FA-93 | anti Human immunodeficiency virus (HIV) 1 Plasma | 抗HIV I 血浆 |
JL-FA-94 | anti Human immunodeficiency virus (HIV) 1 Serum | 抗HIV I 血清 |
JL-FA-95 | anti Human immunodeficiency virus (HIV) 2 Western Blot Tested | 抗HIV 2 免疫印迹 |
JL-FA-96 | anti Human immunodeficiency virus (HIV) 1/2 2 HIV (+) | 抗HIV 1/2 2 HIV阳性 |
JL-FA-97 | Human immunodeficiency virus (HIV) Ag | HIV抗原 |
JL-FA-98 | HIV RNA (quantitative) Plasma | HIV RNA 定量血浆 |
JL-FA-99 | HIV RNA (quantitative) Serum | HIV RNA 定量血清 |
JL-FA-100 | HIV1 Subtype A | HIV1 亚型A |
JL-FA-101 | HIV1 Subtype B | HIV1 亚型B |
JL-FA-102 | HIV1 Subtype C | HIV1 亚型C |
JL-FA-103 | HIV1 Subtype D | HIV1 亚型D |
JL-FA-104 | HIV1 Subtype E | HIV1 亚型E |
JL-FA-105 | HIV1 Subtype F | HIV1 亚型F |
JL-FA-106 | HIV1 Subtype G | HIV1 亚型G |
JL-FA-107 | HIV1 Subtype H | HIV1 亚型H |
JL-FA-108 | HIV1 Subtype J | HIV1 亚型J |
JL-FA-109 | HIV1 Subtype K | HIV1 亚型K |
JL-FA-110 | HIV1 Group O | HIV1 亚型O |
JL-FA-111 | Human immunodeficiency virus (HIV) 2 Antibody Plasma | HIV 2 抗体血浆 |
JL-FA-112 | Human immunodeficiency virus (HIV) 2 Antibody Serum | HIV 2 抗体血清 |
JL-FA-113 | HPV (Human Papiloma Virus) Negative | 人乳状瘤病毒HPV阴性 |
JL-FA-114 | HPV (Human Papiloma Virus) Positive | 人乳状瘤病毒HPV阳性 |
JL-FA-115 | Human immunodeficiency virus (HIV) Antibody HCV Antibody Plasma COINFECTED | HIV 抗体 HCV |
JL-FA-116 | Human T-cell Lymphotropic Virus (HTLV) I/II | 人嗜T淋巴细胞病毒(HTLV) I/II |
JL-FA-117 | Human T-cell Lymphotropic Virus (HTLV) I | 人嗜T淋巴细胞病毒(HTLV) I |
JL-FA-118 | Human T-cell Lymphotropic Virus (HTLV) II | 人嗜T淋巴细胞病毒(HTLV) II |
JL-FA-119 | Jo-1 | 多发性肌炎抗原JO-1 |
JL-FA-120 | IgE < 5,000 Ku/L | IgE < 5,000 Ku/L |
JL-FA-121 | Legionella | 军团杆菌属 |
JL-FA-122 | Leptospira | 军团杆菌属 |
JL-FA-123 | Lyme Disease | 莱姆(氏)病:蜱传播的全身性疾病,常在夏季发生 |
JL-FA-124 | Lyme IgG | 莱姆(氏)病 IGG |
JL-FA-125 | Lyme IgM | 莱姆(氏)病 IGM |
JL-FA-126 | Lyme Disease Neg | 莱姆(氏)病 阴性 |
JL-FA-127 | Malaria | 疟疾 |
JL-FA-128 | Mononucleosis (infectious) | 单核细胞增多症（有传染性的） |
JL-FA-129 | Mononucleosis Negative | 单核细胞增多症阴性 |
JL-FA-130 | Measles Negative | 麻疹 阴性 |
JL-FA-131 | Measles IgG | 麻疹 IGG |
JL-FA-132 | Measles IgM | 麻疹 IGM |
JL-FA-133 | Microsomal Anti-thyroid peroxidase antibody (TPO) Positive Plasma Standard Titer (typically 1,000-3,000 IU/mL) | 微粒体抗甲状腺过氧化物酶抗体 |
JL-FA-134 | Microsomal Anti-thyroid peroxidase antibody (TPO) Negative Plasma | 微粒体抗甲状腺过氧化物酶抗体 |
JL-FA-135 | Anti-mitochondrial antibody (AMA) | 抗线粒体抗体 |
JL-FA-136 | Multiple Sclerosis | 多发性硬化症 |
JL-FA-137 | Mumps IgG | 流行性腮腺炎 IGG |
JL-FA-138 | Mumps Ab IgM | 流行性腮腺炎抗体 IGM |
JL-FA-139 | Mumps Antibody Negative Plasma | 流行性腮腺炎抗体阴性血浆 |
JL-FA-140 | Mumps Antibody Negative Serum | 流行性腮腺炎抗体阴性血清 |
JL-FA-141 | Myeloma Plasma | 骨髓瘤血浆 |
JL-FA-142 | Myeloma IgA | 骨髓瘤IGA |
JL-FA-143 | Myeloma IgE | 骨髓瘤IGE |
JL-FA-144 | Myeloma IgG | 骨髓瘤IGG |
JL-FA-145 | Myeloma IgM | 骨髓瘤IGM |
JL-FA-146 | Mycoplasma | 支原体 |
JL-FA-147 | Mycoplasma Negative | 支原体阴性 |
JL-FA-148 | Mycoplasma IgG | 支原体IGG |
JL-FA-149 | Mycoplasma IgM | 支原体IGM |
JL-FA-150 | Mycoplasma PCR | 支原体PCR |
JL-FA-151 | Normal Human Plasma | 正常人血浆 |
JL-FA-152 | Normal Human Serum | 正常人血清 |
JL-FA-153 | Nuclear Antibody Centromere | 核抗体着丝粒 |
JL-FA-154 | Nuclear Antibody, Speckled ANA | 核抗体，斑点抗核抗体 |
JL-FA-155 | Nuclear Antibody, Nucleolar ANA | 核抗体,核仁抗核抗体 |
JL-FA-156 | Nuclear Antibody, Homogeneous ANA | 核抗体，同质抗核抗体 |
JL-FA-157 | Nuclear Antiobody, Speckled. (ANA) Negative | 核抗体，斑点。抗核抗体阴性 |
JL-FA-158 | P-ANCA (associated neutrophil cytoplasmic antibodies) | 相关的嗜中性粒细胞胞浆抗体 |
JL-FA-159 | Parietal Cell Antibody (PCA) | 胃)壁细胞抗体 |
JL-FA-160 | Parvo positive plasma | 细小病毒阳性血浆 |
JL-FA-161 | Parvo IgM | 细小病毒 IGM |
JL-FA-162 | Parvo IgG | 细小病毒 IGG |
JL-FA-163 | Parvo Negative Plasma | 细小病毒阴性血浆 |
JL-FA-164 | Parvo DNA positive | 细小病毒 DNA 阳性 |
JL-FA-165 | Phospholipid Positive Plasma | 磷脂阳性血浆 |
JL-FA-166 | Prothrombin | 凝血酶原,凝血因子 |
JL-FA-167 | Rheumatoid Factor (RF) <1000 IU/mL | 类风湿因子<1000 IU/mL |
JL-FA-168 | Rheumatoid Factor (RF) 1001-2000 IU/mL | 类风湿因子1001-2000 IU/mL |
JL-FA-169 | Rheumatoid Factor (RF) 2001-4000 IU/mL | 类风湿因子 2001-4000 IU/mL |
JL-FA-170 | Rheumatoid Factor (RF) 4001-5000 IU/mL | 类风湿因子 4001-5000 IU/mL |
JL-FA-171 | Rheumatoid Factor (RF) >5000 IU/mL | 类风湿因子>5000 IU/mL |
JL-FA-172 | Ribonucleoprotein (RNP) Positive | 核糖核蛋白阳性 |
JL-FA-173 | Rubella Chimeric | 风疹 |
JL-FA-174 | Rubella Negative | 风疹阴性 |
JL-FA-175 | Rubella IgG | 风疹IGG |
JL-FA-176 | Rubella IgM | 风疹IGM |
JL-FA-177 | Rubeola Negative Plasma | 风疹阴性血浆 |
JL-FA-178 | Rubeola IgG | 风疹IGG |
JL-FA-179 | Scleroderma (Scl-70) Pos | 胶原沉着病,硬皮病,硬皮症 阳性 |
JL-FA-180 | Scleroderma (Scl-70) Negative | 硬皮病阴性 |
JL-FA-181 | Sickle Cell Fresh Whole Blood | 镰刀形红细胞新鲜全血 |
JL-FA-182 | Smith (SM) | 抗Smith抗体阳性血清（SLE的特征性抗体） |
JL-FA-183 | SMITH RNP | 抗RNP抗体阳性血清（SLE的特征性抗体） |
JL-FA-184 | Smooth Muscle (ASMA) | 抗平滑肌抗体阳性血清 |
JL-FA-185 | Sjogren syndrome antigen A (SSA) Positive | 舍格伦综合征或干燥综合征抗原A 阳性 |
JL-FA-186 | Sjogren syndrome antigen B (SSB) Positive | 舍格伦综合征抗原B 阳性 |
JL-FA-187 | Sjogren syndrome antigen B (SSB) Negative | 舍格伦综合征抗原B阴性 |
JL-FA-188 | Streptolysin O Ab (ASO) | 链球菌溶血素O抗体 |
JL-FA-189 | Syphilis (RPR - Rapid Plasma Reagin) Positive Plasma | 梅毒（梅毒-快速血浆反应）阳性血浆 |
JL-FA-190 | Syphilis (RPR - Rapid Plasma Reagin) Negative Plasma | 梅毒（梅毒-快速血浆反应）阴性血浆 |
JL-FA-191 | Syphilis/ATA/T. pallidum IgG | 梅毒ATA/T，苍白球IGG |
JL-FA-192 | Syphilis/ATA/T. pallidum IgM | 梅毒ATA/T，苍白球IGM |
JL-FA-193 | Systemic Lupus Erythematosus (SLE) Positive | 全身性红斑狼疮阳性 |
JL-FA-194 | Systemic Lupus Erythematosus (SLE) Negative | 全身性红斑狼疮阴性 |
JL-FA-195 | TG/TPO Positive (Standard Titer 1,000 - 3000 IU/mL) | 甲状腺球蛋白/甲状腺过氧化物酶阳性 |
JL-FA-196 | TG/TPO Negative | 甲状腺球蛋白/甲状腺过氧化物酶阴性 |
JL-FA-197 | TTG (Tissue Transglutaminase) | 组织转谷氨酰胺酶 |
JL-FA-198 | TTG (Tissue Transglutaminase) IgA | 组织转谷氨酰胺酶 IGA |
JL-FA-199 | ToRCH (Toxo, Rubella, CMV, HSV) Positive | 优生优育（弓形虫，风疹，巨细胞，单胞）阳性 |
JL-FA-200 | ToRCH (Toxo, Rubella, CMV, HSV) Negative | 优生优育（弓形虫，风疹，巨细胞，单胞）阴性 |
JL-FA-201 | Toxoplasmosis (Toxo) | 弓形虫病 |
JL-FA-202 | Toxoplasmosis (Toxo) IgG | 弓形虫病IGG |
JL-FA-203 | Toxoplasmosis (Toxo) IgM | 弓形虫病IGM |
JL-FA-204 | Thyroglobulin (TG) Positive Plasma | 甲状腺球蛋白阳性血浆 |
JL-FA-205 | Thyroglobulin (TG) Negative | 甲状腺球蛋白阴性 |
JL-FA-206 | Varicella-Zoster Virus (VZV) Negative | 水痘-带状疱疹病毒阴性 |
JL-FA-207 | Varicella-Zoster Virus (VZV) IgG | 水痘-带状疱疹病毒IGG |
JL-FA-208 | Varicella-Zoster Virus (VZV) IgM | 水痘-带状疱疹病毒IGM |
JL-FA-209 | West Nile Virus (WNV) | 西尼罗河脑炎病毒 |
JL-FA-210 | West Nile Virus (WNV) IgM | 西尼罗河脑炎病毒IGM |
美国Seracare
此次研究中，研究人员通过导入这个基因的拷贝，实现了该受体的过量表达。而实际生活中，并不能将这一做法应用到人身上，因而，研究人员将进一步开发靶向这一基因的药物。
一项来自美国俄亥俄州立大学综合癌症中心的证据显示，经基因修饰的免疫细胞或对多发性骨髓瘤的治疗有效果，且这些细胞可在实验室中培养增殖。该研究成果5月28日刊载在Clinical Cancer Research杂志。
研究人员对人类免疫细胞(来自患者的细胞系和骨髓瘤细胞)——T淋巴细胞进行修饰，靶向存在于大多数(占比95%以上)的骨髓瘤细胞中的CS1分子，以期杀死细胞。研究人员在实验室中培养增殖这些修饰细胞，然后将其注入动物模型中，杀死人骨髓瘤细胞。
与对照组t细胞相比，修饰T细胞可以更好地识别过表达CS1的多发性骨髓瘤细胞，并激活。注射修饰T细胞的所有小鼠在接受治疗后存活了44天，而在另外两个对照组中，这一数据只有29%和17%。
这种疗法的一个重要的优势是，这些治疗T细胞在体内有复制潜能，所以或许可以抑制肿瘤生长，长时间内避免复发。
墨尔本的研究人员证明，A型白血病能成功地‘逆转’通过诱骗癌症细胞回到正常发育状态。这一发现使用B-前体急性淋巴细胞白血病(B-ALL)模型，是一种zui常见的影响儿童的癌症。研究人员揭示关闭一个称为Pax5的基因在B-ALL模型中能够诱发癌症，而恢复它的功能能够‘治愈’这种疾病。研究发表在《Genes & Development》期刊上。
研究者之一的刘女士说团队利用一种发展的‘基因开关’技术去抑制然后再活化Pax5在白血病模型中。
“随着其它基因变化一起，失活的Pax5驱动正常血细胞变成白血病细胞，之前已经报道过，”刘女士说。“然而我们*揭示重新复活Pax5能够使细胞重新开始其正常发育并丢失那些类似癌症的特性，有效地治疗白血病。吸引我们的是只是回复Pax5就足够使这些癌细胞恢复常态化，尽管其它基因是改变的。”
白血病中，未成熟白血细胞复制异常并在骨髓中累积，干扰正常血细胞的产生。
刘女士说在儿童B-ALL中Pax5常常是一个‘消失’的基因。“Pax5对于一种白血细胞——b细胞正常发育*的，”她说。“当Pax5功能缺乏抵抗力时，发育中的B细胞陷入一种不成熟状态并且变成癌性的。我们证明恢复Pax5功能，即使是在已经发生癌病的细胞中，移除这个‘阻塞’，使得细胞发育成正常白血细胞。”
Dickins博士说这项研究揭示了Pax5的功能，是约100种已知‘抑制’人类肿瘤的基因之一。“当这些肿瘤抑制基因通过改变DNA而被失活时，肿瘤开始发育，”Dickins博士说。
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In this study, researchers introduced an overexpression of this gene by introducing a copy of this gene. And in real life, this practice can not be applied to people, so the researchers will further develop drugs that target this gene.
Evidence from the Ohio State University Comprehensive Cancer Center shows that genetically modified immune cells or treatments for multiple myeloma can be effective and that these cells can be cultured and proliferated in the laboratory. The research was published May 28 in Clinical Cancer Research.
Researchers have modified human immune cells (cell lines from patients and myeloma cells), T-lymphocytes, to target CS1 molecules present in the majority (over 95%) of myeloma cells in order to kill cell. The researchers cultured and cultured these modified cells in a laboratory and injected them into animal models to kill human myeloma cells.
Modification of T cells allows better identification and activation of CS1-overexpressing multiple myeloma cells as compared to control t-cells. All mice injected with modified T cells survived for 44 days after treatment, compared with only 29% and 17% of the other two controls.
An important advantage of this therapies is that these therapeutic T cells have the potential to replicate in the body and so may be able to inhibit tumor growth and avoid relapse for long periods of time.
Researchers in Melbourne have demonstrated that type A leukemia can successfully 'reverse' by inducing cancer cells to return to their normal developmental state. This finding, using the B-ALL acute lymphoblastic leukemia (B-ALL) model, is one of the most common cancers in children. Researchers have revealed that the closure of a gene called Pax5 is capable of inducing cancer in the B-ALL model, and restoring its function to 'cure' the disease. Research published in "Genes & Development" journal.
Ms. Liu, one of the researchers, said the team took advantage of a newly developed 'gene switch' technique to repress and then reactivate Pax5 in leukemia models.
"As other genetic changes, inactivated Pax5 drives normal blood cells to become leukemic cells, as previously reported," Ms. Liu said. "However, for the first time, we have shown that resuscitation of Pax5 allows cells to restart their normal development and lose those cancers-like properties that effectively treat leukemias, and it is enough to appeal to Pax5 that these cells are restored to normalization, although other genes are changed."
In leukemia, immature white blood cells replicate abnormally and accumulate in the bone marrow, interfering with the production of normal blood cells.
Ms. Liu said Pax5 is often a 'vanishing' gene in children with B-ALL. "Pax5 is essential for the normal development of a white blood cell-b cell," she said. "When Pax5 function lacks resistance, developing B cells plunge into an immature state and become cancerous.We show that restoring Pax5 function, even in cells where cancer has already occurred, removes this 'obstruction' , Making the cells develop into normal white blood cells. "
Dr. Dickins said the study revealed the function of Pax5 and is one of about 100 genes known to 'suppress' human tumors. "Tumors begin to develop when these tumor suppressor genes are inactivated by changing DNA," says Dr. Dickins.
