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【公司名称】 广州健仑生物科技有限公司
【】    杨永汉 
【】 
【腾讯 】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-3室
【企业文化】

Sejnowski说，这个行为结果只是冰山的一角。“该识别系统是非常重要的，”他补充说，它包括认识到其他人，地点，事实，以及发生在过去的事情。有了这个新的发现，科学家们就可以开始更好地理解伽马射线波的识别记忆的作用，他补充道。
在过去的几年里，Whitehead研究所Susan Lindquist实验室的研究人员一直在探究，热休克因子1(HSF1)在支持恶性肿瘤中所起的作用。在正常细胞中，包括热、缺氧和毒素在内的一些应激情况会激活HSF1，HSF1发挥作用维持了蛋白质稳态，帮助细胞度过艰难的时期。癌细胞能够劫持这一热休克反应来让自身受益。两年前，Lindquist实验室证实在癌细胞中HSF1激活了与热休克过程中正常细胞内上调的基因*不同的一组基因。
基于这一研究，该实验室现在发现HSF1不仅对肿瘤中的癌细胞起作用，还影响了称之为间质细胞的肿瘤微环境细胞。在这里HSF1驱动了一种转录程序，其不同于在邻近癌细胞中起作用的程序。HSF1在癌细胞和间质细胞中激活，成为了一个强有力的、互补的组合推动了恶性过程。
在一系列的实验中，Scherz-Shouval和同事们找到了确凿的证据，证实HSF1在包括抗原抗体癌、肺癌、皮肤癌、食管癌、结肠癌和前列腺癌等各种人类肿瘤的癌相关成纤维细胞(CAFs)中激活。并且，他们发现在CAFs中HSF1激活不仅上调了一些支持恶性的基因，还抑制了周围组织中通常触发一种保护性、抗癌免疫反应的一些基因。尽管这样的协同动态看似难以克服，其有可能为治疗干预提供了一个真正的机会。
来自该研究另一个重要的发现是，可利用间质HSF1激活作为一种诊断和预后生物标记。分析来自抗原抗体癌患者的肿瘤样本，科学家们发现间质中HSF1激活与患者的不良预后有关，患者的无病生存率和总生存率降低。此外，研究还发现在来自早期非小细胞肺癌患者的样本中间质HSF1激活也与不良的预后有关。

Sejnowski said the result of this act is only the tip of the iceberg. "The identification system is very important," he added, including recognizing other people, places, facts, and what happened in the past. With this new discovery, scientists can begin to understand better the role of gamma-ray recognition memories, he added.
In the past few years, researchers at the Susan Lindquist Laboratory at the Whitehead Institute have been investigating the role of heat shock factor 1 (HSF1) in supporting malignant tumors. In normal cells, some stress conditions, including heat, hypoxia and toxins, activate HSF1, which acts to maintain protein homeostasis and help cells to pass tough times. Cancer cells can hijack this heat shock response to benefit themselves. Two years ago Lindquist Laboratories confirmed that HSF1 in cancer cells activates a compley different set of genes that are up-regulated in normal cells during heat shock.
Based on this study, the laboratory now found that HSF1 not only affects cancer cells in tumors but also affects tumor microenvironmental cells called stromal cells. Here HSF1 drives a transcription program that is distinct from the programs that play a role in neighboring cancer cells. HSF1 is activated in cancer cells and interstitial cells, becoming a powerful, complementary combination that drives the malignant process.
In a series of experiments, Scherz-Shouval and colleagues found conclusive evidence confirming that HSF1 is involved in the development of cancer-associated fibroblasts in a variety of human tumors including antigen-antibody, lung, skin, esophagus, colon and prostate Cells (CAFs) are activated. And, they found that HSF1 activation in CAFs not only up-regulates some of the genes that support malignancy, but also suppresses some of the genes in surrounding tissues that normally trigger a protective, anti-cancer immune response. While such synergistic dynamics may seem insurmountable, they may offer a real opportunity for therapeutic intervention.
Another important finding from this study is that stromal HSF1 activation can be exploited as a diagnostic and prognostic biomarker. Analyzing tumor samples from patients with antigen-antibody cancers, scientists found that HSF1 activation in the stroma was associated with poor prognosis in patients with a reduction in disease-free survival and overall survival. In addition, the study also found that stromal HSF1 activation in samples from patients with early non-small cell lung cancer is also associated with poor prognosis.