诺如病毒检测试剂盒（免疫捕获法）

广州健仑生物科技有限公司

主要用途：用于检测粪便标本中的诺如病毒抗原，以支持诺如病毒感染的诊断。

产品规格：20T/盒

存储条件：2-30℃

诺如病毒检测试剂盒（免疫捕获法）

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【产品介绍】

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【公司名称】 广州健仑生物科技有限公司
【】    杨永汉 
【】 
【腾讯 】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-3室
【企业文化】

低水平氧气促进HIF-1α的产生与活化，它以两种方式保护细胞。首先，它开启一些基因产生蛋白帮助细胞适应氧气不足。它也能停止DNA复制，防止细胞分裂并增加更多需氧细胞到一个已经很恶劣的环境中。
了解某些细胞忽略HIF-1α的警告并且继续分裂，Gregg Semenza博士及其团队寻找HIF-1α与Cdk1、Cdk2之间的关系，这一蛋白已知调节细胞分裂的决定。他们发现HIF-1α与两者可以相互作用，但是Cdk1增加HIF-1α水平，而Cdk2减低HIF-1α水平。
Semenza的团队怀疑Cdk1与Cdk2按照HIF-1α的指示行事通过细胞的微型“垃圾处理器”称为蛋白酶体标记或者不标记毁灭。但是，当研究人员限制蛋白酶体的功能后，他们发现并没有改变HIF-1α的水平。相反，结果证明是Cdk1与Cdk2通过细胞的溶酶体标记或者不标记毁灭改变了HIF-1α水平。就他们所知，这是*次发现溶酶体牵涉到细胞的分裂决定中。
值得注意的是，在某些肿瘤细胞中，Cdk2能够增加HIF-1α的水平同时也刺激其基因激活作用。有效效应是细胞连续分裂同时应付低氧水平。在培养的细胞中，药物抑制Cdk1以防止HIF-1α水平的下降，并且恢复停止细胞分裂的能力，揭示它们也许能有效治疗某些肿瘤。

Low levels of oxygen promote HIF-1α production and activation, which protects cells in two ways. First, it turns on some gene-producing proteins to help cells adapt to oxygen deficiency. It also stops DNA replication, prevents cell division and adds more aerobic cells to an already harsh environment.
Knowing some cells ignore the warning of HIF-1α and continue to divide, Dr. Gregg Semenza and his team looked for a relationship between HIF-1α and Cdk1, Cdk2, a protein known to regulate cell division. They found that HIF-1α interacted with both, but Cdk1 increased HIF-1α levels and Cdk2 decreased HIF-1α levels.
Semenza's team suspects that Cdk1 and Cdk2, acting on HIF-1α's targets, are called proteasome tags or unmarked annihilation through the cells' tiny "garbage disposers." However, when researchers limited proteasome function, they found that they did not alter HIF-1α levels. Conversely, the results demonstrate that altering HIF-1Î ± levels by lysosomal or unlabeled destruction of Cdk1 and Cdk2 by cells. To the best of their knowledge, this is the first discovery that lysosomes are involved in cell division decisions.
It is noteworthy that in some tumor cells, Cdk2 can increase the level of HIF-1α and also stimulate its gene activation. The effective effect is the continuous division of cells while dealing with hypoxia levels. In cultured cells, the drug inhibits Cdk1 to prevent a decrease in HIF-1α levels and resumes its ability to stop cell division, revealing that they may be effective in treating certain tumors.