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【公司名称】 广州健仑生物科技有限公司
【市场部】 杨永汉
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【腾讯 】 2042552662
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室
对于拟南芥而言,阳光诱导的信号传导过程包括,一个活化的感光分子(光敏色素)结合到转录因子PIF上。这种结合会摧毁PIF,关闭它的目标基因。然而研究人员发现,光敏色素在使PIF摧毁的同时,也判下了自己的死刑,这一指令被立即执行导致信号强度减弱。
“理解植物对光的应答动态,解析其背后的分子机制,有助于我们对作物进行基因工程改造,使其能够更好的适应环境波动,”文章的共同作者,卡内基的王志勇教授说。
研究人员用相互确保摧毁MAD(mutually assured destruction)来形容这种同归于尽的信号减弱机制(MAD本是一种相互威慑的冷战策略)。自然界通过这种机制为关键性的功能保驾护航,而它将为人们提供广泛的启示(从农业到癌症研究)。
对研究干细胞疗效的医学专家来说,zui大的挑战在于,移植物或细胞常常被主体排斥,这就使一些有潜力挽救生命的疗法进展缓慢。但现在,美国科学家或许消灭了这一“拦路虎”,他们将人体多功能干细胞移植进经过遗传改造的猪体内,不仅没有出现排斥现象,这些干细胞还在“新家”茁壮成长。论文发表在一期的美国《国家科学院学报》上,研究人员表示,成果意味着,我们朝着用干细胞治疗和治愈多种慢性疾病更近了一步。
For Arabidopsis, the sun-induced signaling process involves the binding of an activated photosensitizer (phytochrome) to the transcription factor PIF. This combination will destroy the PIF and shut down its target gene. However, researchers found that phytochromes also punished themselves with the death penalty when PIFs were destroyed, and the immediate implementation of this directive resulted in a weaker signal strength.
"Understanding the dynamics of plant response to light and parsing the underlying molecular mechanisms helps us to genetically engineer crops to better adapt to environmental fluctuations," said co-author of the article, Professor Wang Zhiyong of Carnegie .
Researchers use mutually assured destruction (MAD) to describe this end-all signal-weakening mechanism (MAD was a mutually deterrent cold war strategy). Through this mechanism, nature can escort key functions and it will provide a wide range of enlightenment (from agriculture to cancer research).
The biggest challenge for medical specialists studying the effects of stem cells is that the graft or the cells are often rejected by the subject, slowing down some potentially life-saving therapies. But now, American scientists may eliminate this "stumbling block" by transplanting human pluripotent stem cells into genetically engineered pigs. Not only is there no rejection, these stem cells are still thriving in "new home." The paper, published in the latest issue of the Proceedings of the National Academy of Sciences, said the latest results mean that we are one step closer to treating and curing many chronic diseases with stem cells.